Reaction Details Report a problem with these data
Target
Arginase-2, mitochondrial
Ligand
BDBM290420
Substrate
n/a
IC50
125±n/a nM
Citation
Van Zandt, M; Jagdmann, GE Arginase inhibitors as therapeutics US Patent US11389464 Publication Date 7/19/2022
More Info.:
Target
Name:
Arginase-2, mitochondrial
Synonyms:
ARG2 | ARGI2_HUMAN | Arginase II | Kidney-type arginase | Non-hepatic arginase | Type II arginase
Type:
PROTEIN
Mol. Mass.:
38576.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978892
Residue:
354
Sequence:
MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
Inhibitor
Name:
BDBM290420
Synonyms:
(3R,4S)-3-amino-4-(3-boronopropyl)-1-(7-chloro-1,2,3,4- tetrahydroisoquinoline-3-carbonyl)pyrrolidine-3-carboxylic acid | US10098902, Example 56 | US11389464, Example 56
Type:
Small organic molecule
Emp. Form.:
C18H25BClN3O5
Mol. Mass.:
409.672
SMILES:
N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)C1Cc2ccc(Cl)cc2CN1)C(O)=O |r|