Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM50095489
Substrate
n/a
Meas. Tech.
UCHL1 Biochemical IC50 Assay
IC50
55000±n/a nM
Citation
 Stockley, ML; Kemp, MI; Madin, A; Woodrow, MD Sulfonamide-substituted cyanopyrrolidines with activity as DUB inhibitors US Patent  US11414402 Publication Date 8/16/2022 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1
Type:
PROTEIN
Mol. Mass.:
24819.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_974327
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM50095489
Synonyms:
CHEMBL275080 | N-(1-Cyano-pyrrolidin-3-yl)-benzenesulfonamide | N-(1-cyanopyrrolidin-3-yl)benzenesulfonamide | US11414402, Example 5
Type:
Small organic molecule
Emp. Form.:
C11H13N3O2S
Mol. Mass.:
251.305
SMILES:
O=S(=O)(NC1CCN(C1)C#N)c1ccccc1
Structure:
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