Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM570525
Substrate
n/a
Meas. Tech.
Receptor Selection and Amplification (R-SAT) Assays
Ki
0.100±n/a nM
Citation
 Burstein, ES; Olsson, R; Jansson, KE; Sköld, NP; Wahlström, LY; Borgström, BG; Von Wachenfeldt, H; Bergner, MG Compounds, salts thereof and methods for treatment of diseases US Patent  US11440884 Publication Date 9/13/2022 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM570525
Synonyms:
[4-(propan-2-yloxy)phenyl]methyl N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-N-[(4-fluorophenyl)methyl]carbamate (4a) | US11440884, Example 4a
Type:
Small organic molecule
Emp. Form.:
C24H30F2N2O3
Mol. Mass.:
432.5034
SMILES:
CC(C)Oc1ccc(COC(=O)N(Cc2ccc(F)cc2)[C@H]2CCN(C)C[C@H]2F)cc1 |r|
Structure:
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