Reaction Details
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Report a problem with these dataTarget
GTPase KRas [G12D]
Ligand
BDBM573426
Substrate
n/a
Meas. Tech.
KRas G12D Binding Assay
IC50
0.100±n/a nM
Citation
Wang, X; Burns, AC; Christensen, JG; Ketcham, JM; Lawson, JD; Marx, MA; Smith, CR; Allen, S; Blake, JF; Chicarelli, MJ; Dahlke, JR; Dai, D; Fell, JB; Fischer, JP; Mejia, MJ; Newhouse, B; Nguyen, P; O''Leary, JM; Pajk, S; Rodriguez, ME; Savechenkov, P; Tang, TP; Vigers, GP; Zhao, Q; Kahn, DR; Gaudino, J; Hilton, MC KRas G12D inhibitors US Patent US11453683 Publication Date 9/27/2022 More Info.:
Target
Name:
GTPase KRas [G12D]
Synonyms:
GTPase KRas (G12D) | KRAS | KRAS2 | RASK2 | RASK_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21713.12
Organism:
Homo sapiens (Human)
Description:
P01116[G12D]
Residue:
189
Sequence:
MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
Inhibitor
Name:
BDBM573426
Synonyms:
US11453683, Example 284 | US20230279025, Example 284
Type:
Small organic molecule
Emp. Form.:
C28H28ClF5N6O2
Mol. Mass.:
611.006
SMILES:
Oc1cc(Cl)c(c(c1)-c1ncc2c(nc(OC[C@@]34CCCN3C[C@H](F)C4)nc2c1F)N1CC2CCC(C1)N2)C(F)(F)F |r|
Structure:
