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Target
Serine/threonine-protein kinase LATS1
Ligand
BDBM574237
Substrate
n/a
Meas. Tech.
LATS1 Biochemical Assay: Homogenous Time Resolved Fluorescence (HTRF) Assay
IC50
2.00±n/a nM
Citation
 Behnke, D; Berenshteyn, F; Hao, X; Hoffman, T; Jin, Q; Lacoste, A; Lee, C; Liu, J; Liu, Y; Maibaum, JK; Mo, T; Pan, J; Qu, X; Tchorz, J; Xie, YF; Yan, S; Zou, Y 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors US Patent  US11458138 Publication Date 10/4/2022 
Target
Name:
Serine/threonine-protein kinase LATS1
Synonyms:
LATS1 | LATS1_HUMAN | WARTS
Type:
PROTEIN
Mol. Mass.:
126893.90
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774443
Residue:
1130
Sequence:
MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVIQALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKGSKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQNVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYENVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV
  
Inhibitor
Name:
BDBM574237
Synonyms:
US11458138, Example 68 | US11458138, Example 68b
Type:
Small organic molecule
Emp. Form.:
C16H17N5
Mol. Mass.:
279.3397
SMILES:
CCC(C)Nc1nc(nc2cnccc12)-c1ccncc1
Structure:
Search PDB for entries with ligand similarity: