Target
Bcl-2-like protein 1 [1-212]/Bad BH3 Peptide
Ligand
BDBM572205
Substrate
n/a
Meas. Tech.
BCL-XL/Bad BH3 Peptide (BCL-XL Assay)
IC50
14000±n/a nM
Citation
Target
Name:
Bcl-2-like protein 1 [1-212]/Bad BH3 Peptide
Synonyms:
BCL-XL/Bad BH3 Peptide
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Bcl-2-like protein 1 [1-212]
Synonyms:
B2CL1_HUMAN | BCL2L | BCL2L1 | BCLX
Type:
Protein
Mol. Mass.:
23772.86
Organism:
Homo sapiens (Human)
Description:
Q07817[1-212]
Residue:
212
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNR
  
Component 2
Name:
Bcl2-associated agonist of cell death [103-127,M117N]
Synonyms:
BAD | BAD_HUMAN | BBC6 | BCL2L8 | cl2-associated agonist of cell death (BAD)(BH3)
Type:
n/a
Mol. Mass.:
3088.39
Organism:
Homo sapiens (Human)
Description:
Q92934[103-127,M117N]
Residue:
25
Sequence:
NLWAAQRYGRELRRNSDEFVDSFKK
  
Inhibitor
Name:
BDBM572205
Synonyms:
(rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-14-(2,2,2-trifluoroethyl)-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid | US11447504, Example 58 | US11447504, Example 59 | US11447504, Example 60 | US11478451, Example 60
Type:
Small organic molecule
Emp. Form.:
C34H33ClF4N4O3
Mol. Mass.:
657.097
SMILES:
Cc1c-2c(CN(CC(F)(F)F)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C
Structure:
Search PDB for entries with ligand similarity: