Reaction Details Report a problem with these data
Target
Glutamate carboxypeptidase 2
Ligand
BDBM578400
Substrate
n/a
Meas. Tech.
TBD
Ki
0.815±n/a nM
Citation
 Ray, S; Pomper, MG Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer US Patent  US11478558 Publication Date 10/25/2022 
Target
Name:
Glutamate carboxypeptidase 2
Synonyms:
FGCP | FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate carboxypeptidase 2 | Glutamate carboxypeptidase II | Membrane glutamate carboxypeptidase | N-acetylated-alpha-linked acidic dipeptidase I | NAALAD1 | NAALADase I | PSM | PSMA | Prostate-specific membrane antigen | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP
Type:
PROTEIN
Mol. Mass.:
84333.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1497035
Residue:
750
Sequence:
MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKAFLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYPNKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYARTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVKSYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYYDAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFASWDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVDPSKAWGEVKRQIYVAAFTVQAAAETLSEVA
  
Inhibitor
Name:
BDBM578400
Synonyms:
US11478558, Compound L10
Type:
Small organic molecule
Emp. Form.:
C46H69BrN8O17
Mol. Mass.:
1085.987
SMILES:
OC(=O)CC[C@H](NC(=O)N[C@@H](CCCCN(Cc1ccc(Br)cc1)C(=O)[C@H]1CC[C@H](CNC(=O)CCC(N2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)C(O)=O)CC1)C(O)=O)C(O)=O |r,wU:29.30,10.9,wD:5.5,26.26,(18.53,-5.21,;17.2,-5.98,;17.2,-7.52,;15.87,-5.21,;14.53,-5.98,;13.2,-5.21,;11.87,-5.98,;10.53,-5.21,;10.53,-3.67,;9.2,-5.98,;7.86,-5.21,;6.53,-5.98,;5.2,-5.21,;3.86,-5.98,;2.53,-5.21,;1.2,-5.98,;1.2,-7.52,;2.53,-8.29,;2.53,-9.83,;3.86,-10.6,;5.2,-9.83,;6.53,-10.6,;5.2,-8.29,;3.86,-7.52,;-.14,-5.21,;-.14,-3.67,;-1.47,-5.98,;-2.8,-5.21,;-4.14,-5.98,;-4.14,-7.52,;-5.47,-8.29,;-6.81,-7.52,;-8.14,-8.29,;-9.47,-7.52,;-8.14,-9.83,;-9.47,-10.6,;-9.47,-12.14,;-10.81,-12.91,;-10.81,-14.45,;-12.14,-15.22,;-12.14,-16.76,;-10.81,-17.53,;-9.47,-16.76,;-8.14,-17.53,;-9.47,-15.22,;-13.47,-17.53,;-14.81,-16.76,;-14.81,-15.22,;-16.14,-15.99,;-16.14,-17.53,;-17.48,-18.3,;-14.81,-18.3,;-16.14,-14.45,;-16.14,-12.91,;-14.81,-12.14,;-14.81,-10.6,;-16.14,-9.83,;-17.48,-10.6,;-16.14,-8.29,;-13.47,-12.91,;-12.14,-12.14,;-8.14,-12.91,;-8.14,-14.45,;-6.81,-12.14,;-2.8,-8.29,;-1.47,-7.52,;7.86,-3.67,;9.2,-2.9,;6.53,-2.9,;13.2,-3.67,;14.53,-2.9,;11.87,-2.9,)|
Structure:
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