Reaction Details Report a problem with these data
Target
Rho-associated protein kinase 2 [1-552]
Ligand
BDBM578461
Substrate
n/a
Meas. Tech.
Z-lyte assay
IC50
6.50±n/a nM
Citation
 Skucas, E; Liu, KG; Kim, J; Poyurovsky, MV; Mo, R; Zhang, J Inhibitors of Rho associated coiled-coil containing protein kinase US Patent  US11479533 Publication Date 10/25/2022 
Target
Name:
Rho-associated protein kinase 2 [1-552]
Synonyms:
KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho-associated protein kinase 2 (ROCK2)
Type:
Enzyme
Mol. Mass.:
63353.50
Organism:
Homo sapiens (Human)
Description:
aa 1-552
Residue:
552
Sequence:
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQI
  
Inhibitor
Name:
BDBM578461
Synonyms:
N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-2-((3-(methylamino)-propyl)amino)acetamide | US11479533, Example 42
Type:
Small organic molecule
Emp. Form.:
C22H27N5O2
Mol. Mass.:
393.4821
SMILES:
CNCCCNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(OC)c1
Structure:
Search PDB for entries with ligand similarity: