Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM50202658
Substrate
n/a
Meas. Tech.
Biochemical Inhibition Assay
IC50
6.36±n/a nM
Citation
 Bair, KW; Baumeister, TR; Dragovich, P; Liu, X; Patel, S; Yuen, P; Zak, M; Zhao, G; Zhang, Y; Zheng, X Amido spirocyclic amide and sulfonamide derivatives US Patent  US11485745 Publication Date 11/1/2022 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM50202658
Synonyms:
CHEMBL3893879 | US10730889, Example 49 | US11485745, Example 367
Type:
Small organic molecule
Emp. Form.:
C21H30N4O3
Mol. Mass.:
386.4879
SMILES:
CC(C)(C)OC(=O)N1CCC2(CC2CNC(=O)N2Cc3ccncc3C2)CC1
Structure:
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