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Target
Cation-dependent mannose-6-phosphate receptor
Ligand
BDBM582013
Substrate
n/a
Meas. Tech.
General M6PR Binding Assay
IC50
75±n/a nM
Citation
 Bradley, BB; Thomas, EJ; K., PG; G., LJ; D., TE M6PR CELL SURFACE RECEPTOR BINDING COMPOUNDS AND CONJUGATES WIPO 0:0 (2023) [PubMed] 
Target
Name:
Cation-dependent mannose-6-phosphate receptor
Synonyms:
M6PR | MPR46 | MPRD | MPRD_HUMAN
Type:
PROTEIN
Mol. Mass.:
30989.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_492874
Residue:
277
Sequence:
MFPFYSCWRTGLLLLLLAVAVRESWQTEEKTCDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACSPEISHLSVGSILLVTFASLVAVYVVGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM
  
Inhibitor
Name:
BDBM582013
Synonyms:
WO2023288015, Compound Table12B.772
Type:
Small organic molecule
Emp. Form.:
C111H172N24O46P4
Mol. Mass.:
2702.5816
SMILES:
O[C@@H]1[C@@H](CCP(O)(O)=O)O[C@H](Oc2ccc(NC(=O)NCCCCc3cn(CCCCC(NC(=O)[C@@H](CCCCn4cc(CCCCNC(=O)Nc5ccc(O[C@H]6O[C@H](CCP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]6O)cc5)nn4)NC(=O)C(CCCn4cc(CCCCNC(=O)Nc5ccc(O[C@H]6O[C@H](CCP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]6O)cc5)nn4)N(=O)CCCn4cc(CCCCNC(=O)Nc5ccc(O[C@H]6O[C@H](CCP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]6O)cc5)nn4)C(=O)NCCOCCOCCOCCOCCC(O)=O)nn3)cc2)[C@@H](O)[C@H]1O
Structure:
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