Reaction Details
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Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]
Ligand
BDBM585773
Substrate
n/a
Meas. Tech.
Cbl-b Displacement Assay (Cbl-b Inhibition Assay high)
IC50
1.5±n/a nM
Citation
Sands, AT; Bence, NF; Zapf, CW; Cohen, F; Wang, C; Cummins, T; Tanaka, H; Shunatona, H; Cardozo, M; Weiss, D; Gosling, J Cyano cyclobutyl compounds for CBL-B inhibition and uses thereof US Patent US11530229 Publication Date 12/20/2022 More Info.:
Target
Name:
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]
Synonyms:
CBLB | CBLB_HUMAN | E3 ubiquitin-protein ligase CBL-B [36-427] | RNF56
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45487.32
Organism:
Homo sapiens (Human)
Description:
aa 36-427 (sequence in paper SEQ ID No: 1)
Residue:
392
Sequence:
PKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFD
Inhibitor
Name:
BDBM585773
Synonyms:
US11530229, Compound 1
Type:
Small organic molecule
Emp. Form.:
C24H25N7O
Mol. Mass.:
427.5016
SMILES:
Cc1cc(nc(n1)C1CC1)C(=O)Nc1cccc(c1)[C@@]1(Cc2nncn2C)C[C@@H](C1)C#N |r,wU:28.34,wD:19.21,(-8.63,1.82,;-7.3,1.05,;-5.96,1.82,;-4.63,1.05,;-4.63,-.49,;-5.96,-1.26,;-7.3,-.49,;-5.96,-2.8,;-6.73,-4.13,;-5.19,-4.13,;-3.3,1.82,;-3.3,3.36,;-1.96,1.05,;-.63,1.82,;-.63,3.36,;.71,4.13,;2.04,3.36,;2.04,1.82,;.71,1.05,;3.37,1.05,;2.04,.28,;2.04,-1.26,;.79,-2.16,;1.27,-3.63,;2.81,-3.63,;3.28,-2.16,;4.75,-1.69,;4.46,-.04,;5.55,1.05,;4.46,2.14,;7.09,1.05,;8.63,1.05,)|
Structure:
