Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 9 [133-239]
Ligand
BDBM565363
Substrate
n/a
Meas. Tech.
BRD9 bromodomain TR-FRET Competition Binding Assay
IC50
<10±n/a nM
Citation
 Ruppel, SK; Yang, Z; Lowe, JT; Voigt, JH; Netherton, M Compounds and uses thereof US Patent  US11560381 Publication Date 1/24/2023 
Target
Name:
Bromodomain-containing protein 9 [133-239]
Synonyms:
BRD9 | BRD9_HUMAN | Bromodomain-containing protein 9 (BRD9)(133-239)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12383.34
Organism:
Homo sapiens (Human)
Description:
aa 133-239
Residue:
107
Sequence:
PAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSK
  
Inhibitor
Name:
BDBM565363
Synonyms:
US11414416, Compound D130 | US11560381, Compound D130
Type:
Small organic molecule
Emp. Form.:
C45H50N6O11
Mol. Mass.:
850.9121
SMILES:
COc1cc(cc(OC)c1CN1CCC(CC1)OC1CCN(C1)C(=O)CCOCCOc1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1)-c1cn(C)c(=O)c2cnccc12
Structure:
Search PDB for entries with ligand similarity: