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Target
thrombin
Ligand
BDBM594981
Substrate
n/a
Meas. Tech.
Enzymatic Assay for Thrombin
Ki
<500±n/a nM
Citation
 Cutshall, NS; Gage, JL; Gruswitz, FA; Khalaf, J; Little, TL; Metz, M; Nguyen, JH; Nollert von Specht, PK; Tsoung, J; Cicirelli, M; Goldstein, SR; Keshipeddy, SK; Kwon, DY; Lemus, RH; Vaddela, SB MASP-2 inhibitors and methods of use US Patent  US11584714 Publication Date 2/21/2023 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM594981
Synonyms:
US11584714, Compound 1008
Type:
Small organic molecule
Emp. Form.:
C19H27N5O2
Mol. Mass.:
357.45
SMILES:
N[C@H](C1CCCC1)C(=O)N1CC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N |r|
Structure:
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