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Target
Protein cereblon
Ligand
BDBM594700
Substrate
n/a
Meas. Tech.
Fluorescence Direct Binding Asaay
Kd
<1.000±n/a nM
Citation
 Nasveschuk, CG; Dey, F; Goergler, A; Kuhn, B; Norcross, R; Roever, S; Schmid, P Spirocyclic compounds US Patent  US11584748 Publication Date 2/21/2023 
Target
Name:
Protein cereblon
Synonyms:
CRBN | CRBN_HUMAN
Type:
PROTEIN
Mol. Mass.:
50537.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116917
Residue:
442
Sequence:
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
  
Inhibitor
Name:
BDBM594700
Synonyms:
8-(Pyrazolo[1,5-a]pyridine-3-carbonyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione | US11584748, Example 67
Type:
Small organic molecule
Emp. Form.:
C15H15N5O3
Mol. Mass.:
313.3113
SMILES:
O=C(N1CCC2(CC1)NC(=O)NC2=O)c1cnn2ccccc12
Structure:
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