Reaction Details Report a problem with these data
Target
Inward rectifier potassium channel 2
Ligand
BDBM600755
Substrate
n/a
Meas. Tech.
thallium-flux assay
IC50
>30000±n/a nM
Citation
 Swale, DR; Foil, LD Method for controlling hematophagous or sap-feeding arthropods US Patent  US11632953 Publication Date 4/25/2023 
Target
Name:
Inward rectifier potassium channel 2
Synonyms:
Cardiac inward rectifier potassium channel | IRK-1 | IRK1 | Inward rectifier K(+) channel Kir2.1 | KCNJ2 | KCNJ2_HUMAN | Potassium channel, inwardly rectifying subfamily J member 2 | hIRK1
Type:
PROTEIN
Mol. Mass.:
48281.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1515520
Residue:
427
Sequence:
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI
  
Inhibitor
Name:
BDBM600755
Synonyms:
US11632953, Compound 13 | VU0652943
Type:
Small organic molecule
Emp. Form.:
C17H24F3N3O
Mol. Mass.:
343.3872
SMILES:
CC1CC(C)CN(C1)C(=O)Cn1nc(c2CCCCc12)C(F)(F)F
Structure:
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