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Target
Tyrosine-protein phosphatase non-receptor type 1 [1-405]
Ligand
BDBM205457
Substrate
n/a
Meas. Tech.
Metabolic Measurements
Ki
10000±n/a nM
Citation
 Tonks, N; Krishnan, N Treatment of Rett syndrome US Patent  US11660306 Publication Date 5/30/2023 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1 [1-405]
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1
Type:
n/a
Mol. Mass.:
46535.71
Organism:
Homo sapiens (Human)
Description:
P18031[1-405]
Residue:
405
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSY
  
Inhibitor
Name:
BDBM205457
Synonyms:
(2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid | Celastrol | US11660306, Example Celastrol | acs.jmedchem.1c00409_ST.357
Type:
Small organic molecule
Emp. Form.:
C29H38O4
Mol. Mass.:
450.6096
SMILES:
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@]12C)C(O)=O |r,c:1,6,11,t:9|
Structure:
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