Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK2 [808-1132]
Ligand
BDBM604269
Substrate
n/a
Meas. Tech.
JAK2 HTRF Enzyme Activity Assay
IC50
<100±n/a nM
Citation
 Liu, K; Douty, B; Levy, D; Wu, L; Yao, W; Yue, EW Tricyclic urea compounds as JAK2 V617F inhibitors US Patent  US11661422 Publication Date 5/30/2023 
Target
Name:
Tyrosine-protein kinase JAK2 [808-1132]
Synonyms:
JAK2 | JAK2 (aa 808-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 JH1 (808-1132)
Type:
Protein
Mol. Mass.:
39171.39
Organism:
Homo sapiens (Human)
Description:
O60674[808-1132]
Residue:
335
Sequence:
FRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM604269
Synonyms:
US11661422, Example 5
Type:
Small organic molecule
Emp. Form.:
C28H35N5O3S
Mol. Mass.:
521.674
SMILES:
CS(=O)(=O)C1CCN(Cc2ccc(cc2)-c2cc3c4CN(C5CCCCC5)C(=O)Nc4cnc3[nH]2)CC1
Structure:
Search PDB for entries with ligand similarity: