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Target
Tyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H]
Ligand
BDBM604314
Substrate
n/a
Meas. Tech.
JAK2 LanthaScreen JH2-WT Binding Assay
IC50
<100±n/a nM
Citation
 Liu, K; Douty, B; Levy, D; Wu, L; Yao, W; Yue, EW Tricyclic urea compounds as JAK2 V617F inhibitors US Patent  US11661422 Publication Date 5/30/2023 
Target
Name:
Tyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H]
Synonyms:
JAK2 | JAK2_HUMAN | Tyrosine-protein kinase JAK2 JH2 (536-812)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31754.64
Organism:
Homo sapiens (Human)
Description:
aa 536-812
Residue:
277
Sequence:
VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD
  
Inhibitor
Name:
BDBM604314
Synonyms:
9-(4-(4-Acetylpiperazin- 1-yl)phenyl)-2-(tert- butyl)-4-methyl-8-(4-((4- (methylsulfonyl)piperidin- 1-yl)methyl)phenyl)- 1,2,4,7-tetrahydro-3H- pyrrolo[3',2':5,6]pyrido[3, 4-d]pyrimidin-3-one, trifluoroacetic acid salt | US11661422, Example 18
Type:
Small organic molecule
Emp. Form.:
C39H49N7O4S
Mol. Mass.:
711.916
SMILES:
CN1C(=O)N(Cc2c1cnc1[nH]c(c(-c3ccc(cc3)N3CCN(CC3)C(C)=O)c21)-c1ccc(CN2CCC(CC2)S(C)(=O)=O)cc1)C(C)(C)C
Structure:
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