Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]
Ligand
BDBM604315
Substrate
n/a
Meas. Tech.
JAK2 LanthaScreen JH2-V617F Binding Assay
IC50
<100±n/a nM
Citation
 Liu, K; Douty, B; Levy, D; Wu, L; Yao, W; Yue, EW Tricyclic urea compounds as JAK2 V617F inhibitors US Patent  US11661422 Publication Date 5/30/2023 
Target
Name:
Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H]
Synonyms:
JAK2 | JAK2_HUMAN | Tyrosine-protein kinase JAK2 JH2 (536-812) V617F
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31802.68
Organism:
Homo sapiens (Human)
Description:
aa 536-812 V617F
Residue:
277
Sequence:
VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD
  
Inhibitor
Name:
BDBM604315
Synonyms:
US11661422, Example 19
Type:
Small organic molecule
Emp. Form.:
C39H46N8O4S
Mol. Mass.:
722.899
SMILES:
CC(C(N)=O)n1cc(cn1)-c1ccc(cc1)-c1c([nH]c2ncc3N(C)C(=O)N(Cc3c12)C(C)(C)C)-c1ccc(CN2CCC(CC2)S(C)(=O)=O)cc1
Structure:
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