Reaction Details Report a problem with these data
Target
Apelin
Ligand
BDBM610889
Substrate
n/a
Meas. Tech.
Measurement of Apelin Receptor Agonist Activity
EC50
1.000±n/a nM
Citation
 Ikeda, T; Kobayashi, Y; Miyoshi, N; Suzuki, O; Nagayama, T; Tsuji, T; Smith, LH; Pinkerton, AB Azole derivatives as apelin receptor agonist US Patent  US10626096 Publication Date 4/21/2020 
Target
Name:
Apelin
Synonyms:
APEL | APEL_HUMAN | APJ endogenous ligand | APLN | Apelin-13 | Apelin-28 | Apelin-31 | Apelin-36
Type:
PROTEIN
Mol. Mass.:
8579.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108275
Residue:
77
Sequence:
MNLRLCVQALLLLWLSLTAVCGGSLMPLPDGNGLEDGNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
  
Inhibitor
Name:
BDBM610889
Synonyms:
2-({[4-(2,6-Dimethoxyphenyl)-5-(5-methylfuran-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}methyl)-7-methyl-4H-pyrido[1,2-a]pyrimidin-4-one | US10626096, Example 2
Type:
Small organic molecule
Emp. Form.:
C25H23N5O4S
Mol. Mass.:
489.546
SMILES:
COc1cccc(OC)c1-n1c(SCc2cc(=O)n3cc(C)ccc3n2)nnc1-c1ccc(C)o1 |(-.34,-2.29,;.43,-.96,;1.97,-.96,;2.74,-2.29,;4.28,-2.29,;5.05,-.96,;4.28,.37,;5.05,1.71,;6.59,1.71,;2.74,.37,;1.97,1.71,;.44,1.87,;-.59,.72,;-2.1,1.04,;-3.13,-.1,;-4.63,.22,;-5.66,-.93,;-7.17,-.6,;-5.19,-2.39,;-6.22,-3.53,;-5.74,-5,;-6.77,-6.14,;-4.23,-5.32,;-3.2,-4.17,;-3.68,-2.71,;-2.65,-1.57,;.12,3.37,;1.46,4.14,;2.6,3.11,;4.06,3.59,;5.31,2.68,;6.56,3.59,;6.08,5.05,;7.17,6.14,;4.54,5.05,)|
Structure:
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