Reaction Details Report a problem with these data
Target
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Ligand
BDBM613045
Substrate
n/a
Meas. Tech.
Apoptosis Inhibition Assay
EC50
<100.0±n/a nM
Citation
 Zhang, Z; Wang, X; Huang, S; Jiang, X; Li, L; Zhang, Z; Han, J Apoptosis inhibitors US Patent  US11725000 Publication Date 8/15/2023 
Target
Name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Synonyms:
1.3.5.1 | Iron-sulfur subunit of complex II | SDH | SDH1 | SDHB | SDHB_HUMAN | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Type:
PROTEIN
Mol. Mass.:
31643.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117429
Residue:
280
Sequence:
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
  
Inhibitor
Name:
BDBM613045
Synonyms:
US11725000, Compound 308
Type:
Small organic molecule
Emp. Form.:
C33H34F3N3O3S
Mol. Mass.:
609.702
SMILES:
Cc1cc(nc(n1)S(=O)CCC(OCc1ccc(F)cc1F)c1ccccc1)-c1cc(F)c(=O)n(CC2CCCCC2)c1
Structure:
Search PDB for entries with ligand similarity: