Reaction Details
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GTPase KRas [G12D]
Ligand
BDBM573647
Substrate
n/a
Meas. Tech.
Inhibition of KRas G12D-mediated Phosphorylation of ERK
IC50
0.500±n/a nM
Citation
Wang, X; Burns, AC; Christensen, JG; Ketcham, JM; Lawson, JD; Marx, MA; Smith, CR; Allen, S; Blake, JF; Chicarelli, MJ; Dahlke, JR; Dai, D; Fell, JB; Fischer, JP; Mejia, MJ; Newhouse, B; Nguyen, P; O''Leary, JM; Pajk, S; Rodriguez, ME; Savechenkov, P; Tang, TP; Vigers, GP; Zhao, Q; Kahn, DR; Gaudino, J; Hilton, MC KRAS G12D INHIBITORS US Patent US20230279025 Publication Date 9/7/2023 More Info.:
Target
Name:
GTPase KRas [G12D]
Synonyms:
GTPase KRas (G12D) | KRAS | KRAS2 | RASK2 | RASK_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21713.12
Organism:
Homo sapiens (Human)
Description:
P01116[G12D]
Residue:
189
Sequence:
MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
Inhibitor
Name:
BDBM573647
Synonyms:
US11453683, Example 441 | US20230279025, Example 441
Type:
Small organic molecule
Emp. Form.:
C37H43F2N7O4
Mol. Mass.:
687.7786
SMILES:
CCc1c(F)ccc2cc(O)cc(-c3ncc4c(nc(OC[C@]56CCCN5[C@@H](COC(=O)N(C)C)CC6)nc4c3F)N3CC4CCC(C3)N4)c12 |r|
Structure:
