Reaction Details Report a problem with these data
Target
Furin [108-574]
Ligand
BDBM621419
Substrate
n/a
Meas. Tech.
Furin Enzyme Assay
IC50
0.020±n/a nM
Citation
 Axten, JM; Cheung, M; Demartino, MP; Guan, HA; Hu, Y; Miller, AB; Qin, D; Wu, C; Zhang, Z; Lin, X Furin inhibitors US Patent  US11773078 Publication Date 10/3/2023 
Target
Name:
Furin [108-574]
Synonyms:
Furin (108-574)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50656.86
Organism:
Homo sapiens (Human)
Description:
aa 108-574
Residue:
467
Sequence:
DVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTA
  
Inhibitor
Name:
BDBM621419
Synonyms:
US11773078, Example 171
Type:
Small organic molecule
Emp. Form.:
C31H40Cl2N8O3
Mol. Mass.:
643.607
SMILES:
CNC(=O)NCC1CCN(Cc2cc(Oc3cnc(nc3)N3CCN(CCCO)CC3)nc(c2)-c2cc(Cl)cc(Cl)c2)CC1
Structure:
Search PDB for entries with ligand similarity: