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Target
Alpha-ketoglutarate-dependent dioxygenase FTO
Ligand
BDBM50599025
Substrate
n/a
Meas. Tech.
In Vitro Inhibition Assay Method
IC50
160±n/a nM
Citation
 Rana, TM BROAD SPECTRUM ANTI-CANCER COMPOUNDS US Patent  US20230322715 Publication Date 10/12/2023 
Target
Name:
Alpha-ketoglutarate-dependent dioxygenase FTO
Synonyms:
FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752
Type:
PROTEIN
Mol. Mass.:
58263.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1515854
Residue:
505
Sequence:
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQLLEAKP
  
Inhibitor
Name:
BDBM50599025
Synonyms:
CHEMBL5207866 | US20230322715, Compound TR-FTO-40
Type:
Small organic molecule
Emp. Form.:
C16H21F3N2OS
Mol. Mass.:
346.411
SMILES:
FC(F)(F)Sc1ccc(CNCC2(COC2)N2CCCC2)cc1
Structure:
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