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Target
Receptor-type tyrosine-protein kinase FLT3 [564-960]
Ligand
BDBM311132
Substrate
n/a
Meas. Tech.
FLT3 Kinase Test
IC50
4954±n/a nM
Citation
 Hoffmann, M; Dahmann, G; Gnamm, C; Fandrick, DR; Scott, J; McCarthy, C Pyrazolyl-substituted heteroaryls and their use as medicaments US Patent  US10155751 Publication Date 12/18/2018 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3 [564-960]
Synonyms:
CD135 | FLK2 | FLT3 | FLT3 (aa 564-960) | FLT3_HUMAN | STK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45855.41
Organism:
Homo sapiens (Human)
Description:
P36888[564-960]
Residue:
397
Sequence:
HKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG
  
Inhibitor
Name:
BDBM311132
Synonyms:
US10155751, Example 19
Type:
Small organic molecule
Emp. Form.:
C22H29N5O2
Mol. Mass.:
395.498
SMILES:
CC(C)Cn1cc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2c(C)n(C)nc2c1 |r|
Structure:
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