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Target
Glycogen [starch] synthase, liver
Ligand
BDBM634583
Substrate
n/a
Meas. Tech.
The GYS2 coupled enzyme assay
IC50
>100000±n/a nM
Citation
 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof US Patent  US11814367 Publication Date 11/14/2023 
Target
Name:
Glycogen [starch] synthase, liver
Synonyms:
2.4.1.11 | GYS2 | GYS2_HUMAN | Glycogen [starch] synthase, liver
Type:
PROTEIN
Mol. Mass.:
80993.15
Organism:
Homo sapiens
Description:
ChEMBL_118993
Residue:
703
Sequence:
MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN
  
Inhibitor
Name:
BDBM634583
Synonyms:
US11814367, Compound 32
Type:
Small organic molecule
Emp. Form.:
C27H29FN4O3
Mol. Mass.:
476.5426
SMILES:
CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ccncc1=O)c1ccccc1 |r|
Structure:
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