Reaction Details Report a problem with these data
Target
Fatty acid-binding protein 5
Ligand
BDBM635749
Substrate
n/a
Meas. Tech.
FABP3, FABP5, and FABP7 Binding Assay
Ki
120±20 nM
Citation
 Ojima, I; Kaczocha, M; Awwa, M; Pepe, A TRUXILLIC ACID MONOESTER-DERIVATIVES AS SELECTIVE FABP5 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF US Patent  US20230365488 Publication Date 11/16/2023 
Target
Name:
Fatty acid-binding protein 5
Synonyms:
FABP5 | FABP5_HUMAN | Fatty acid binding protein epidermal | Fatty acid-binding protein 5 (FABP5)
Type:
Enzyme
Mol. Mass.:
15164.79
Organism:
Homo sapiens (Human)
Description:
Q01469
Residue:
135
Sequence:
MATVQQLEGRWRLVDSKGFDEYMKELGVGIALRKMGAMAKPDCIITCDGKNLTIKTESTLKTTQFSCTLGEKFEETTADGRKTQTVCNFTDGALVQHQEWDGKESTITRKLKDGKLVVECVMNNVTCTRIYEKVE
  
Inhibitor
Name:
BDBM635749
Synonyms:
US20230365488, Compound 1f
Type:
Small organic molecule
Emp. Form.:
C32H25NO5
Mol. Mass.:
503.5446
SMILES:
OC(=O)[C@@H]1C([C@H]([C@@H]1c1ccccc1)C(=O)Oc1cccc(c1)-c1ccc2CC(=O)Nc2c1)c1ccccc1 |r,wU:6.7,3.2,wD:5.14,(-7.56,-3.35,;-7.56,-1.81,;-8.89,-1.04,;-6.23,-1.04,;-4.74,-1.44,;-4.34,.05,;-5.83,.45,;-6.6,1.78,;-5.83,3.12,;-6.6,4.45,;-8.14,4.45,;-8.91,3.12,;-8.14,1.78,;-3.01,.82,;-1.67,.05,;-3.01,2.36,;-1.67,3.13,;-1.67,4.67,;-.34,5.44,;1,4.67,;1,3.13,;-.34,2.36,;2.33,2.36,;2.33,.82,;3.66,.05,;5,.82,;6.46,.34,;7.37,1.59,;8.91,1.59,;6.46,2.84,;5,2.36,;3.66,3.13,;-3.97,-2.77,;-4.74,-4.11,;-3.97,-5.44,;-2.43,-5.44,;-1.66,-4.11,;-2.43,-2.77,)|
Structure:
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