Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [75-147]
Ligand
BDBM50539805
Substrate
n/a
Meas. Tech.
TR-FRET BRD4 Binding Assay
Ki
<10.00±n/a nM
Citation
 Thatcher, GR; Xiong, R; Zhao, J; Li, Y Pyridinone-based epigenetic modifiers and uses thereof US Patent  US11840533 Publication Date 12/12/2023 
Target
Name:
Bromodomain-containing protein 4 [75-147]
Synonyms:
BRD4 | BRD4_HUMAN | Bromo domain 1 | Bromodomain-containing protein 4 (BD1) | Bromodomain-containing protein 4 (BRD4) Bromo 1 | Bromodomain-containing protein 4 (BRD4)(BD1) | Bromodomain-containing protein 4 (BRD4)(Bromo 1) | Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) | Bromodomain-containing protein 4 Bromodomain 1 (BRD4-1) | Bromodomain-containing protein 4 Domain 1 | HUNK1
Type:
n/a
Mol. Mass.:
8856.55
Organism:
Homo sapiens (Human)
Description:
BD1 (75-147 aa) of O60885
Residue:
73
Sequence:
WKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV
  
Inhibitor
Name:
BDBM50539805
Synonyms:
CHEMBL4644032 | US11840533, Compound 72
Type:
Small organic molecule
Emp. Form.:
C31H29N5O2
Mol. Mass.:
503.5943
SMILES:
Cn1cc(-c2cc(c3ccn(c3c2)C(C)(c2ccccn2)c2ccccn2)C(C)(C)O)c2cc[nH]c(=O)c12
Structure:
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