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Target
Monoglyceride lipase
Ligand
BDBM640384
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
0.002±n/a nM
Citation
 Chen, G; Huang, C; Liang, JT Radiolabelled MGL pet ligands US Patent  US11839663 Publication Date 12/12/2023 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM640384
Synonyms:
(S)-(2-Chloro-6-fluorophenyl)(3-(3,5-difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H- pyrazolo[3,4-c]pyridin-6-yl)methanone | US11839663, Example 1
Type:
Small organic molecule
Emp. Form.:
C21H17ClF3N3O
Mol. Mass.:
419.827
SMILES:
C[C@@H]1N(CCc2c1nn(C)c2-c1cc(F)cc(F)c1)C(=O)c1c(F)cccc1Cl |r|
Structure:
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