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Target
Nuclear receptor subfamily 1 group D member 1
Ligand
BDBM643201
Substrate
n/a
Meas. Tech.
FRET Assay for REV-ERB Ligands
IC50
<1000±n/a nM
Citation
 Walker, JK; Burris, TP; Sitaula, S; Chatterjee, A; D''Cunha, NC; Jacobsen, EJ; Blinn, JR REV-ERB AGONISTS US Patent  US20240002380 Publication Date 1/4/2024 
Target
Name:
Nuclear receptor subfamily 1 group D member 1
Synonyms:
EAR-1 | EAR1 | HREV | NR1D1 | NR1D1_HUMAN | Rev-erbA-alpha | THRAL | V-erbA-related protein 1
Type:
PROTEIN
Mol. Mass.:
66822.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_958222
Residue:
614
Sequence:
MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDNSNGSFQSLTQGCPTYFPPSPTGSLTQDPARSFGSIPPSLSDDGSPSSSSSSSSSSSSFYNGSPPGSLQVAMEDSSRVSPSKSTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMNLANNQLSSQCPLETSPTQHPTPGPMGPSPPPAPVPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTLAAQRHNEALNGLRQAPSSYPPTWPPGPAHHSCHQSNSNGHRLCPTHVYAAPEGKAPANSPRQGNSKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ
  
Inhibitor
Name:
BDBM643201
Synonyms:
US20240002380, Example 68
Type:
Small organic molecule
Emp. Form.:
C20H14N2O
Mol. Mass.:
298.338
SMILES:
O(c1ccc2ncccc2n1)c1ccccc1-c1ccccc1
Structure:
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