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Target
Biofilm regulatory protein A
Ligand
BDBM50033767
Substrate
n/a
Meas. Tech.
Inhibition of the activity of Gtfs determined by Zymographic Assay
IC50
74500±9800 nM
Citation
 Velu, SE; Wu, H; Zhang, Q; Nijampatnam, B Streptococcus mutans glucosyl transferase inhibitors for dental caries therapy US Patent  US11866416 Publication Date 1/9/2024 
Target
Name:
Biofilm regulatory protein A
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
43911.21
Organism:
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Description:
Q8DVR0
Residue:
406
Sequence:
MKIGKKILIMLVTIFLTSLVALGVYATSIYNFSLGEFSKTFKDYGTGSGKDVIADEKPFSILLMGVDTGSSERTSKWEGNSDSMILVTVNPKTKKTTMTSLERDILVKLSGSKTNDQTGYDAKLNAAYAAGGAKMAIMTVQDMLDIKIDKYVQINMEGLVQLVDAVGGITVTNHFDFPISIEEHEPEFTASVEPGTHKINGEQALVYSRMRYDDPDGDYGRQKRQREVISKVLKKILALDSVSKYRKILSAVSKNMQTNIEISSSTIPKLLGYSDALKSIRTYQLKGEGTTIDGGSYQLVTSKELLKAQNRIKGQLGLKKSTAENLKTTASLYENFYGGDTSIYDSSSSASDYSSSGNYSGSSSDYGSSSSYGSNSSSGSSSDYSGQNSYNQGNYQQPAAGTGIGN
  
Inhibitor
Name:
BDBM50033767
Synonyms:
3,3',4',5',7-pentahydroxy flavone | 3,7,3',4',5'-Pentahydroxyflavone | 3,7-Dihydroxy-2-(3,4,5-trihydroxy-phenyl)-chromen-4-one | 3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one | CHEMBL170405 | NSC-407331 | ROBINETIN | US11866416, Compound PAY
Type:
Small organic molecule
Emp. Form.:
C15H10O7
Mol. Mass.:
302.2357
SMILES:
Oc1ccc2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O
Structure:
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