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Target
Uracil nucleotide/cysteinyl leukotriene receptor
Ligand
BDBM646602
Substrate
n/a
Meas. Tech.
GPR17 cAMP Assay Protocol
IC50
12.0±n/a nM
Citation
 GALLEY, G; GOBBI, L; GUBA, W; MAZUNIN, D; PINARD, E; RICCI, A PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES US Patent  US20240025883 Publication Date 1/25/2024 
Target
Name:
Uracil nucleotide/cysteinyl leukotriene receptor
Synonyms:
GPR17 | GPR17_HUMAN
Type:
PROTEIN
Mol. Mass.:
41013.71
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1353471
Residue:
367
Sequence:
MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCYLLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESSLSAKSEL
  
Inhibitor
Name:
BDBM646602
Synonyms:
6-chloro-N-[5-(2-cyanoethyl)- 4,6-dimethoxy-pyrimidin-2- yl]-7-(difluoromethylthio)-1H- indole-3-sulfonamide | US20240025883, Example 107
Type:
Small organic molecule
Emp. Form.:
C18H16ClF2N5O4S2
Mol. Mass.:
503.931
SMILES:
COc1nc(NS(=O)(=O)c2c[nH]c3c(SC(F)F)c(Cl)ccc23)nc(OC)c1CCC#N
Structure:
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