Reaction Details Report a problem with these data
Target
GTPase KRas
Ligand
BDBM647804
Substrate
n/a
Meas. Tech.
KRAS WT Biochemical Assay
IC50
1.55±n/a nM
Citation
 Landry, ML; Nilewski, C; Siu, M; Villemure, E; Wang, Y; Wei, B; Ashley, MA; Do, S; Gazzard, LJ; Green, SA AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF US Patent  US20240025919 Publication Date 1/25/2024 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM647804
Synonyms:
US20240025919, Compound 31
Type:
Small organic molecule
Emp. Form.:
C31H34F5N7O3
Mol. Mass.:
647.6388
SMILES:
C[C@@H]1Oc2nc(c(F)c3nc(OC[C@@H]4CC[C@H]5COCCN45)nc(N4C[C@H]5CC[C@H](N5)[C@@H]14)c23)-c1cc(N)c(F)c(C)c1C(F)(F)F |r|
Structure:
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