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Target
Bromodomain-containing protein 4 [75-147]
Ligand
BDBM50092325
Substrate
n/a
Meas. Tech.
FP Competitive Binding Assay (No.350)
Temperature
298.15±n/a K
Ki
4842±29 nM
Comments
extracted
Citation
 Wang, S; Ran, X; Zhao, Y; Yang, C; Liu, L; Bai, L; McEachern, D; Stuckey, J; Meagher, JL; Sun, D; Li, X; Zhou, B; Karatas, H; Luo, R; Chinnaiyan, A; Asangani, IA BET bromodomain inhibitors and therapeutic methods using the same US Patent  US9675697 Publication Date 6/13/2017 
Target
Name:
Bromodomain-containing protein 4 [75-147]
Synonyms:
BRD4 | BRD4_HUMAN | Bromo domain 1 | Bromodomain-containing protein 4 (BD1) | Bromodomain-containing protein 4 (BRD4) Bromo 1 | Bromodomain-containing protein 4 (BRD4)(BD1) | Bromodomain-containing protein 4 (BRD4)(Bromo 1) | Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) | Bromodomain-containing protein 4 Bromodomain 1 (BRD4-1) | Bromodomain-containing protein 4 Domain 1 | HUNK1
Type:
n/a
Mol. Mass.:
8856.55
Organism:
Homo sapiens (Human)
Description:
BD1 (75-147 aa) of O60885
Residue:
73
Sequence:
WKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV
  
Inhibitor
Name:
BDBM50092325
Synonyms:
CHEMBL3581654 | US9675697, RX-27
Type:
Small organic molecule
Emp. Form.:
C18H17ClN4O
Mol. Mass.:
340.807
SMILES:
COc1cc2c(cc1-c1c(C)nn(C)c1C)[nH]c1ccnc(Cl)c21 |(5.4,2.98,;5.4,1.69,;4.01,.88,;2.65,1.65,;1.32,.88,;1.32,-.65,;2.65,-1.41,;4.01,-.65,;5.4,-1.46,;5.55,-3.05,;4.58,-3.9,;7.12,-3.38,;7.92,-1.99,;9.2,-1.85,;6.85,-.79,;7.11,.47,;,-1.41,;-1.32,-.65,;-2.67,-1.41,;-3.97,-.65,;-3.97,.88,;-2.67,1.65,;-2.68,2.94,;-1.32,.88,)|
Structure:
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