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Target
Toll-like receptor 6
Ligand
BDBM649747
Substrate
n/a
Meas. Tech.
LR2 Assays
IC50
400±n/a nM
Citation
 NATALA, SR; WRASIDLO, WJ; STOCKING, EM COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING US Patent  US20240043395 Publication Date 2/8/2024 
Target
Name:
Toll-like receptor 6
Synonyms:
CD_antigen=CD286 | TLR6 | TLR6_HUMAN
Type:
PROTEIN
Mol. Mass.:
91889.28
Organism:
Homo sapiens
Description:
ChEMBL_108413
Residue:
796
Sequence:
MTKDKEPIVKSFHFVCLMIIIVGTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSELVPYLEKEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAAFNMKLTLVTENNDVKS
  
Inhibitor
Name:
BDBM649747
Synonyms:
(3-fluoro-4-hydroxy-5-(((4- methylpiperazin-1- yl)imino)methyl)phenyl)(4-(4- (pyrrolidin-1- yl)phenyl)piperidin-1- yl)methanone | US20240043395, Compound 163
Type:
Small organic molecule
Emp. Form.:
C28H36FN5O2
Mol. Mass.:
493.6161
SMILES:
CN1CCN(CC1)\N=C\c1cc(cc(F)c1O)C(=O)N1CCC(CC1)c1ccc(cc1)N1CCCC1
Structure:
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