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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM179827
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
pH
6±n/a
Ki
3.80±n/a nM
IC50
10.00±n/a nM
Comments
extracted
Citation
 Barrett, SD; Germain, BD; Uzieblo, A; Ciske, FL; Endres, GW; Kornilov, A; Maxey, KM; O'Malley, JP; Owen, TA Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions US Patent  US9676712 Publication Date 6/13/2017 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM179827
Synonyms:
US9676712, 1C
Type:
Small organic molecule
Emp. Form.:
C24H35NO4
Mol. Mass.:
401.539
SMILES:
O[C@H](CCCCc1ccccc1)\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O |r|
Structure:
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