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Target
RAF proto-oncogene serine/threonine-protein kinase
Ligand
BDBM313550
Substrate
n/a
Meas. Tech.
In Vitro Raf Activity Determination
IC50
331±n/a nM
Citation
Aversa, RJ; Burger, MT; Dillon, MP; Dineen, Jr., TA; Lou, Y; Nishiguchi, GA; Ramurthy, S; Rico, AC; Rauniyar, V; Sendzik, M; Subramanian, S; Setti, LQ; Taft, BR; Tanner, HR; Wan, L Compounds and compositions as RAF kinase inhibitors US Patent US10167279 Publication Date 1/1/2019
More Info.:
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase
Synonyms:
C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene
serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase
RAF | Serine/threonine-protein kinase C-Raf | cRaf
Type:
Serine/threonine-protein kinase
Mol. Mass.:
73082.52
Organism:
Homo sapiens (Human)
Description:
P04049
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
Inhibitor
Name:
BDBM313550
Synonyms:
N-(3-(2-((2- hydroxyethyl)amino)-6- (tetrahydro-2H-pyran-4- yl)pyridin-4-yl-4- methylphenyl)-3- (trifluoromethyl) benzamide | US10167279, Example 174
Type:
Small organic molecule
Emp. Form.:
C27H28F3N3O3
Mol. Mass.:
499.5247
SMILES:
Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(NCCO)nc(c1)C1CCOCC1