Reaction Details Report a problem with these data
Target
Amine oxidase [flavin-containing] B
Ligand
BDBM11020
Substrate
BDBM11019
Meas. Tech.
MAO Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
>1000000±n/a nM
Comments
no inhibition
Citation
 Hubalek, F; Binda, C; Khalil, A; Li, M; Mattevi, A; Castagnoli, N; Edmondson, DE Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. J Biol Chem 280:15761-6 (2005) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_BOVIN | Amine oxidase [flavin-containing] B | MAO-B | MAOB | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B | Monoamine oxidase type B
Type:
PROTEIN
Mol. Mass.:
58428.94
Organism:
Bos taurus
Description:
ChEMBL_1501478
Residue:
520
Sequence:
MSSKCDVVVVGGGISGMAAAKLLHDSGLNVIVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNHILRLSKELGLETYKVNEVERLIHHTKGKSYPFRGSFPSVWNPITYLDHNNLWRTMDDMGREIPSDAPWKAPLAEQWDLMTMKELLDKICWTESSKQLAILFVNLCVTAEIHEVSALWFLWYVKQCGGTTRIFSTSNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIHIDQTGENVLVETLNHELYEAKYVISAVPPVLGMKIHFNPPLPMMRNQLITRVPLGSVIKSIVYYKEPFWRNMDYCGSMIIEGEEAPVAYALDDTKPDGSYPAIIGFILAHKARKLARLTKEERLKKLCDLYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTSYFPPGIMTQYGRVLRQPVGRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWLPEPESVDVPAKPITTTFLQRHLPSVPGLLKLIGLTTIFSATALGFLAHKRGLLVRI
  
Inhibitor
Name:
BDBM11020
Synonyms:
1,4-diphenyl-2-butene (DPB) | [(2E)-4-phenylbut-2-en-1-yl]benzene
Type:
Small organic molecule
Emp. Form.:
C16H16
Mol. Mass.:
208.2982
SMILES:
C(\C=C\Cc1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM11019
Synonyms:
1-methyl-4-(1-methyl-1H-pyrrol-2-yl)-1,2,3,6-tetrahydropyridine | 1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine | MMTP
Type:
Small organic molecule
Emp. Form.:
C11H16N2
Mol. Mass.:
176.2581
SMILES:
CN1CCC(=CC1)c1cccn1C |c:4|
Structure:
Search PDB for entries with ligand similarity: