Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM322472
Substrate
n/a
Meas. Tech.
Human alpha7 nAChR Binding Assay
Ki
>30000±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; Koenig, G; Mcriner, AJ Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors US Patent  US10183938 Publication Date 1/22/2019 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM322472
Synonyms:
(R)-N-(2,2-dimethylquinuclidin-3-yl)imidazo[1,2-a]pyrazine-6-carboxamide | US10183938, Compound (R)-225
Type:
Small organic molecule
Emp. Form.:
C16H21N5O
Mol. Mass.:
299.3708
SMILES:
CC1(C)[C@H](NC(=O)c2cn3ccnc3cn2)C2CCN1CC2 |wU:3.3,(-1.65,-1.64,;-3.19,-1.64,;-2.42,-2.98,;-3.19,-.1,;-1.85,.67,;-.52,-.1,;-.52,-1.64,;.82,.67,;2.15,-.1,;3.48,.67,;4.95,.19,;5.85,1.44,;4.95,2.68,;3.48,2.21,;2.15,2.98,;.82,2.21,;-4.52,.67,;-5.16,-.29,;-5.16,-1.45,;-4.52,-2.41,;-5.85,-1.64,;-5.85,-.1,)|
Structure:
Search PDB for entries with ligand similarity: