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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM323038
Substrate
n/a
Meas. Tech.
FLAP Binding Assay (Test A)
IC50
230±n/a nM
Citation
 Broddefalk, JO; Emtenäs, HF; Granberg, KL; Lemurell, MA; Pettersen, DT; Plowright, AT; Ulander, LJ Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors US Patent  US10183947 Publication Date 1/22/2019 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM323038
Synonyms:
N,1-Dimethyl-4-[({(1R,2R)-2-[4-(5- methyl-1H-pyrazol-3-yl)benzoyl]- cyclohexyl}carbonyl)amino]-1H-pyrazole- 5-carboxamide | US10183947, Example 21 | US10508119, Example 21 | US11001589, Example 21
Type:
Small organic molecule
Emp. Form.:
C24H28N6O3
Mol. Mass.:
448.5175
SMILES:
CNC(=O)c1c(NC(=O)[C@@H]2CCCC[C@H]2C(=O)c2ccc(cc2)-c2cc(C)[nH]n2)cnn1C |r|
Structure:
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