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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM323048
Substrate
n/a
Meas. Tech.
FLAP Binding Assay (Test A)
IC50
190±n/a nM
Citation
 Broddefalk, JO; Emtenäs, HF; Granberg, KL; Lemurell, MA; Pettersen, DT; Plowright, AT; Ulander, LJ Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors US Patent  US10183947 Publication Date 1/22/2019 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM323048
Synonyms:
4-[({(1R,2R and 1S,2S)-2-[2-Chloro-4- (1H-pyrazol-5-yl)benzoyl] cyclohexyl}carbonyl)amino]-1-methyl-1H- pyrazole-5-carboxamide | US10183947, Example 31 | US10508119, Example 31
Type:
Small organic molecule
Emp. Form.:
C22H23ClN6O3
Mol. Mass.:
454.909
SMILES:
Cn1ncc(NC(=O)C2CCCCC2C(=O)c2ccc(cc2Cl)-c2ccn[nH]2)c1C(N)=O |w:8.7,13.14|
Structure:
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