Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50015088
Substrate
n/a
Meas. Tech.
HDAC Inhibition Assay
IC50
133±n/a nM
Citation
 Hooker, JM; Wang, C; Schroeder, FA Imaging histone deacetylases with a radiotracer using positron emission tomography US Patent  US10188756 Publication Date 1/29/2019 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50015088
Synonyms:
(E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-3-phenylacrylamide | CHEMBL154574 | N-Hydroxy-3-phenyl-acrylamide | US10188756, Compound CN86 | trans-N-Hydroxy-3-phenyl-acrylamide
Type:
Small organic molecule
Emp. Form.:
C9H9NO2
Mol. Mass.:
163.1733
SMILES:
ONC(=O)\C=C\c1ccccc1
Structure:
Search PDB for entries with ligand similarity: