Reaction Details
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RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]
Ligand
BDBM189734
Substrate
n/a
Meas. Tech.
Raf IC50 Assay
Temperature
298.1500±n/a K
IC50
190±n/a nM
Comments
extracted
Citation
Zhou, C; Zhang, G Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors US Patent US9670203B2 Publication Date 6/6/2017 More Info.:
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]
Synonyms:
C-Raf (Y340D/Y341D) | RAF1_HUMAN | RAF1 | RAF
Type:
n/a
Mol. Mass.:
38958.87
Organism:
Human
Description:
PV3805, from Invitrogen
Residue:
343
Sequence:
SQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
Inhibitor
Name:
BDBM189734
Synonyms:
US9670203, Compound 1.49
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
482.12
SMILES:
Fc1cc(F)c(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)cc1F |r|
Structure:
