Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM337792
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
260±n/a nM
Citation
 Fürstner, C; Ackerstaff, J; Straub, A; Meier, H; Tinel, H; Zimmermann, K; Tersteegen, A; Zubov, D; Kast, R; Schamberger, J; Schäfer, M Substituted uracils and use thereof US Patent  US9751843 Publication Date 9/5/2017 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM337792
Synonyms:
3-[3-Chloro-2-(trifluoromethyl)benzyl]-1-[4-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl]-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid | US9751843, 186
Type:
Small organic molecule
Emp. Form.:
C24H18ClF3N4O4
Mol. Mass.:
518.872
SMILES:
Cc1cc(C)n(n1)-c1ccc(cc1)-n1cc(C(O)=O)c(=O)n(Cc2cccc(Cl)c2C(F)(F)F)c1=O
Structure:
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