Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM13017
Substrate
BDBM13015
Meas. Tech.
Radiochemical Assay for PNMT Activity
pH
8±n/a
Temperature
310.15±n/a K
Ki
560±40 nM
Citation
McMillan, FM; Archbold, J; McLeish, MJ; Caine, JM; Criscione, KR; Grunewald, GL; Martin, JL Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase. J Med Chem 47:37-44 (2004) [PubMed] Article
More Info.:
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase
Type:
Enzyme
Mol. Mass.:
30916.97
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
283
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
Inhibitor
Name:
BDBM13017
Synonyms:
1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHEMBL26717 | SKF 29661
Type:
Small organic molecule
Emp. Form.:
C9H12N2O2S
Mol. Mass.:
212.269
SMILES:
NS(=O)(=O)c1ccc2CCNCc2c1