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Target
Tyrosine-protein kinase JAK1 [850-1154]
Ligand
BDBM348969
Substrate
n/a
Meas. Tech.
JAK1 Inhibition Assay
IC50
<100±n/a nM
Citation
 Menet, CJ; Van Rompaey, LJ; Fletcher, SR; Blanc, J; Jouannigot, N; Hodges, AJ; Smits, KK Compounds useful for the treatment of degenerative and inflammatory diseases US Patent  US10206907 Publication Date 2/19/2019 
Target
Name:
Tyrosine-protein kinase JAK1 [850-1154]
Synonyms:
JAK1 | JAK1 (aa 850-1154) | JAK1A | JAK1B | JAK1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
34949.64
Organism:
Homo sapiens (Human)
Description:
P23458[850-1154]
Residue:
305
Sequence:
EQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
  
Inhibitor
Name:
BDBM348969
Synonyms:
N-(5-(4-(4-(4- chlorophenyl)piperidine-1- carbonyl(phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide | US10206907, Compound 86
Type:
Small organic molecule
Emp. Form.:
C28H26ClN5O2
Mol. Mass.:
499.991
SMILES:
Clc1ccc(cc1)C1CCN(CC1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Structure:
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