Target

Ligand

Substrate

Meas. Tech.

Chk1 Enzymatic Assay

pH

7.5±n/a

Temperature

303.15±n/a K

Citation

 Foloppe, N; Fisher, LM; Howes, R; Kierstan, P; Potter, A; Robertson, AG; Surgenor, AE Structure-based design of novel Chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity. J Med Chem 48:4332-45 (2005) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,   Solution Info,  Assay Method

Name:

Serine/threonine-protein kinase Chk1

Synonyms:

CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

54443.02

Organism:

Homo sapiens (Human)

Description:

gi_166295192

Residue:

476

Sequence:

MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM14801

Synonyms:

2-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}(methyl)amino)ethan-1-ol | 2-[(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-yl)-methylamino]-ethanol | furanopyrimidine compound 3

Type:

Small organic molecule

Emp. Form.:

C21H19N3O2

Mol. Mass.:

345.3945

SMILES:

CN(CCO)c1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

Chktide

Synonyms:

n/a

Type:

Peptide

Mol. Mass.:

2707.16

Organism:

n/a

Description:

n/a

Residue:

23

Sequence:

KKKVSRSGLYRSPSMPENLNRPR