Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM347454
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
0.040±n/a nM
Citation
 Wright, DL; Anderson, AC; Van Heyst, M; Ononye, S Substituted tropolone derivatives and methods of use US Patent  US9790158 Publication Date 10/17/2017 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM347454
Synonyms:
MO-OH-TM | US9790158, 5
Type:
Small organic molecule
Emp. Form.:
C16H16O5
Mol. Mass.:
288.2952
SMILES:
COc1ccc(c(OC)c1OC)-c1ccccc(O)c1=O
Structure:
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