Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 10
Ligand
BDBM15638
Substrate
EGF receptor peptide
Meas. Tech.
Enzyme Inhibition Assay
Ki
2500±n/a nM
Citation
 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors. J Med Chem 50:1280-7 (2007) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 10
Synonyms:
JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3)
Type:
Enzyme
Mol. Mass.:
52586.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
464
Sequence:
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
  
Inhibitor
Name:
BDBM15638
Synonyms:
4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-(1-(4-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide | 4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-[1-(4-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide | Pyrrole Carboxamide Analog 6i
Type:
Small organic molecule
Emp. Form.:
C22H18Cl2N4O2
Mol. Mass.:
441.31
SMILES:
OCC(NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
EGF receptor peptide
Synonyms:
Epidermal Growth Factor Receptor Peptide (EGFRP)
Type:
Peptide
Mol. Mass.:
2318.63
Organism:
n/a
Description:
n/a
Residue:
21
Sequence:
KRELVEPLTPSGEAPNQALLR