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Target
Methionine aminopeptidase
Ligand
BDBM17868
Substrate
BDBM17848
Meas. Tech.
MetAP Inhibition Assay
pH
7.5±n/a
Temperature
295.15±n/a K
IC50
16000±1800 nM
Citation
 Douangamath, A; Dale, GE; D'Arcy, A; Almstetter, M; Eckl, R; Frutos-Hoener, A; Henkel, B; Illgen, K; Nerdinger, S; Schulz, H; Mac Sweeney, A; Thormann, M; Treml, A; Pierau, S; Wadman, S; Oefner, C Crystal structures of Staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate. J Med Chem 47:1325-8 (2004) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase
Synonyms:
MAP1_STAAW | MetAP | Methionine Aminopeptidase (MAP) | Peptidase M | SaMetAP-1 | map
Type:
Enzyme
Mol. Mass.:
27494.40
Organism:
Staphylococcus aureus
Description:
P0A079
Residue:
252
Sequence:
MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDENFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTKDGPILTTKIEEE
  
Inhibitor
Name:
BDBM17868
Synonyms:
(2S)-2-amino-4-(methylsulfanyl)-1-(pyridin-2-yl)butan-1-one | keto-heterocycle inhibitor, 2
Type:
Small organic molecule
Emp. Form.:
C10H14N2OS
Mol. Mass.:
210.296
SMILES:
CSCC[C@H](N)C(=O)c1ccccn1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM17848
Synonyms:
1-[(2S)-2-amino-4-(methylsulfanyl)butanoyl]-N-(4-nitrophenyl)pyrrolidine-2-carboxamide | Met-Pro-pNA
Type:
Small organic molecule
Emp. Form.:
C16H22N4O4S
Mol. Mass.:
366.435
SMILES:
CSCC[C@H](N)C(=O)N1CCCC1C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure:
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